BioResource in Adult Infectious Disease

Summary

BioAID 2024-2029 is a an adaptive multi‑centre research tissue bank (RTB) to enable observational studies in adult infectious diseases. We combine host and pathogen samples with routinely collected health records from adult hospital patients with suspected or proven infectious disease, with capacity to recall participants for secondary studies. We aim to provide the foundation for discovery and validation of novel biomarkers and multivariable models for diagnostic, prognostic and therapeutic stratification of adult patients with infectious diseases, and for identification of novel therapeutic targets.

Study design

BioAID incorporates multiple recruitment streams that are implemented for designated periods of time specified by the executive committee, subject to written applications to the RTB that specify the rationale, target population, inclusion/exclusion criteria and target sample size.  We use a deferred consent approach. In each recruitment stream, routine clinical sampling will be accompanied by collection of index research samples among adult participants who fulfil the stream-specific inclusion criteria.