Mahdad Noursadeghi
I am Professor of Infectious Diseases at UCL, and Honorary Consultant in Infectious Diseases at University College London Hospital. I lead research on the immunology of infectious disease to improve diagnosis, predictions of infection or treatment outcomes, and to identify new approaches to vaccination or immunomodulatory treatment of disease. Our current projects focus predominantly on tuberculosis and respiratory virus infections including COVID-19. We combine, laboratory science, epidemiology and bioinformatics to investigate the correlates of protective and pathogenic immunity. We use sequencing technology to make molecular and systems level assessment of human in vivo immune responses in clinical samples and undertake mechanistic studies in laboratory models.
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My projects
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Adaptive multi-centre research tissue bank to enable discovery and validation of novel biomarkers and multivariable models for diagnostic, prognostic and therapeutic stratification of adult patients with infectious diseases, and for identification of novel therapeutic targets.
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The Mucosal Immunity in Human Coronavirus Challenge (MusiCC) project is a global consortium that will lay the crucial groundwork needed to develop the next generation of COVID-19 vaccines that could not only prevent severe disease but also stop SARS-CoV-2 and other coronaviruses from infecting people in the first place, thus blocking the spread of the virus.
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Identification of common genetic variation responsible for variation in human in vivo immune responses to a standardised antigenic challenge in the tuberculin skin test.
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Genome-wide transcriptional profiling and TCR sequencing of the site of standardised antigenic challenge to study in vivo human immune responses to Mycobacterium tuberculosis.
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Discovery and validation of host-response blood transcriptional biomarkers of infection to diagnose prevalent, infection, predict incidence disease, stratify treatment effects and provide test-of-cure.
